Handbook of Physics in Medicine and Biology
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In considering ways that physics has helped advance biology and medicine, what typically comes to mind are the various tools used by researchers and clinicians. We think of the optics put to work in microscopes, endoscopes, and lasers; the advanced diagnostics permitted through magnetic, x-ray, and ultrasound imaging; and even the nanotools, that allow us to tinker with molecules. We build these instruments in accordance with the closest thing to absolute truths we know, the laws of physics, but seldom do we apply those same constants of physics to the study of our own carbon-based beings, such as fluidics applied to the flow of blood, or the laws of motion and energy applied to working muscle.
Instead of considering one aspect or the other, Handbook of Physics in Medicine and Biology explores the full gamut of physics’ relationship to biology and medicine in more than 40 chapters, written by experts from the lab to the clinic.
The book begins with a basic description of specific biological features and delves into the physics of explicit anatomical structures starting with the cell. Later chapters look at the body's senses, organs, and systems, continuing to explain biological functions in the language of physics.
The text then details various analytical modalities such as imaging and diagnostic methods. A final section turns to future perspectives related to tissue engineering, including the biophysics of prostheses and regenerative medicine.
The editor’s approach throughout is to address the major healthcare challenges, including tissue engineering and reproductive medicine, as well as development of artificial organs and prosthetic devices. The contents are organized by organ type and biological function, which is given a clear description in terms of electric, mechanical, thermodynamic, and hydrodynamic properties. In addition to the physical descriptions, each chapter discusses principles of related clinical diagnostic methods and technological aspects of therapeutic applications. The final section on regenerative engineering, emphasizes biochemical and physiochemical factors that are important to improving or replacing biological functions. Chapters cover materials used for a broad range of applications associated with the replacement or repair of tissues or entire tissue structures.
endocytosis used during vesicular internalization.20 Conversely, the process by which materials are delivered from within the cell to the plasma membrane occurs during exocytosis.21 Together, endocytosis and exocytosis influence membrane surface area homeostasis and the recycling of cellular materials that includes transmembrane receptors and lipids (Figure 1.6). Clathrin-mediated endocytosis permits the uptake of essential nutrients and the internalization of activated receptors from the cell
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proton to move back into the cell, through another transmembrane protein, ATP synthase. 22.214.171.124 Empirical Valence Bond Model Often scientists want to study biochemical bond breaking and forming processes, such as the breaking of a covalent bond to H, and the forming of a new covalent bond to H. Modeling these types of chemical reactions requires the use of a quantum mechanical (QM) treatment to describe the reacting fragments, coupled with a classical, molecular mechanics (MM) simulation of the
and voltage. The conductance of the potassium ions was modeled by Hodgkin and Huxley, as represented by Equations 4.13 and 4.14: g K = g Kn 4 , (4.13) 4-4 Anatomical Physics dn = αn (1 − n) − βnn, dt (4.14) where g–K is a constant that is equal to the maximum value of g K and has units of conductance/cm2 and n is a dimensionless variable that can only take values from 0 to 1. The latter has been described as the “portion of particles in a certain position (e.g., at the inside of the
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